Therapeutic Use of Pulsed Electromagnetic Field Therapy Reduces ProstateVolume and Lower UrinaryTract Symptoms in Benign Prostatic Hyperplasia

publikation_icon
Abstract 

Background: Benign prostatic hyperplasia (BPH) etiology remains poorly understood, but chronic low-grade inflammation plays a role. Pulsed electromagnetic field
therapy (PEMF) (1-50 Hz) is effective in reducing tissue inflammation.


Objectives: We designed a pilot study to evaluate the effects of PEMF on prostate
volume (PV) in BPH.


Materials and Methods: This is a prospective interventional trial on 27 naive patients
with BPH and lower urinary tract symptoms (LUTS). At baseline (V0), all patients had
blood tests, transrectal ultrasound, and questionnaires (IPSS, IIEF-15) and received
a perineal PEMF device (Magcell®Microcirc, Physiomed Elektromedizin). PEMF was
delivered on perineal area 5 minutes twice daily for 28 days, then (V1) all baseline
evaluations were repeated. Afterward, nine patients continued therapy for 3 more
months (PT group) and 15 discontinued (FU group). A 4-month evaluation (V2) was
performed in both groups.


Results: A reduction was observed both at V1 and at V2 in PV: PVV0 44.5 mL (38.0;61.6)
vs PVV1 42.1 mL (33.7;61.5, P = .039) vs PVV2 41.7mL (32.7;62.8, P = .045). IPSS was
reduced both at V1 and at V2: IPSSV0 11 (5.7;23.2) vs IPSSV1 10 (6;16, P = .045) vs
IPSSV2 9 (6;14, P = .015). Baseline IPSS was related to IPSS reduction both at V1
(rs = 0.313;P = .003) and at V2 (rs = 0.664;P < .001). PV reduction in patients without
metabolic syndrome (ΔPVV1nMetS −4.7 mL, 95%CI −7.3;-2.0) was greater than in affected patients (ΔPVV1MetS 1.7 mL, 95%CI −2.69;6.1)(P = .017, Relative RiskMetS = 6).
No changes were found in gonadal hormones or sexual function.


Discussion: PEMF was able to reduce PV after 28 days of therapy. Symptoms improved in a short time, with high compliance and no effects on hormonal and sexual
function or any side effects. Patients with moderate-severe LUTS and without MetS
seem to benefit more from this treatment.

 

Tenuta M, Tarsitano MG, Mazzotta P, Lucchini L, Sesti F, Fattorini G, Pozza C, Olivieri V, Naro F, Gianfrilli D, Lenzi A, Isidori AM, Pofi R. Therapeutic Use of Pulsed Electromagnetic Field Therapy Reduces ProstateVolume and Lower UrinaryTract Symptoms in Benign Prostatic Hyperplasia. Andrology. 2020 Feb 23. doi: 10.1111/andr.12775. [Epub ahead of print] PubMed PMID: 32090492.